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Apolipoprotein B as an independent predictor of arterial stiffness in systemic lupus erythematosus patients
Author(s) -
Kwankaew Jirateep,
Leelawattana Rattana,
Saignam Anchalee,
Siripaitoon Boonjing,
Ueaareewongsa Parichat,
Juthong Siriporn
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12384
Subject(s) - arterial stiffness , medicine , pulse wave velocity , apolipoprotein b , blood pressure , endocrinology , creatinine , cardiology , gastroenterology , cholesterol
Aim To determine the relationship of apolipoprotein B (Apo‐B) and arterial stiffness determined by brachial‐ankle pulse wave velocity (ba PWV ) in systemic lupus erythematosus ( SLE ) subjects. Methods Eighty‐seven Thai SLE subjects with inactive disease activity were studied. Fasting blood was collected for creatinine, glucose, lipid profiles, Apo‐B and Apo‐A1. Pearson correlation and stepwise‐linear regression were used for the analysis. Results The mean age of the subjects was 36.69 ± 10.85 years; 6.90% of them had stage 3 or more severe chronic kidney disease, 49.40% took anti‐hypertensive drugs and 4.60% had abnormal glucose metabolism. The mean value for ba PWV was 1332 ± 274.12 cm/s. Thirty‐six percent of the subjects had increased arterial stiffness with mean Apo‐B levels of 1.05 ± 0.31 g/L compared to 0.94 ± 0.24 in normal arterial stiffness. There were correlations of ba PWV with age, systolic blood pressure ( BP ), diastolic BP and creatinine clearance. Apo‐B tended to be associated with ba PWV ( P = 0.06) whereas low‐density lipoprotein cholesterol did not ( P = 0.2). By multiple regression analysis, systolic BP , age and Apo‐B were the significant predictors of ba PWV . Conclusion Apo‐B was independently associated with arterial stiffness in SLE subjects.