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Study of endothelial dysfunction in patients of psoriatic arthritis by flow mediated and nitroglycerine mediated dilatation of brachial artery
Author(s) -
Sharma Aman,
Reddy Mallapu Hithesh,
Sharma Kusum,
Dogra Sunil,
Vijayvergiya Rajesh
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12336
Subject(s) - medicine , brachial artery , endothelial dysfunction , psoriatic arthritis , cardiology , vasodilation , disease , coronary artery disease , blood pressure
Objective To study endothelial dysfunction in patients with psoriatic arthritis (PsA) without risk factors for cardiovascular disease. Methods Forty patients with PsA according to Classification Criteria for Psoriatic Arthritis ( CASPAR ) criteria and forty age‐ and sex‐matched controls were included. Patients with risk factors for cardiovascular disease were excluded. Endothelial function was assessed by measuring endothelial‐dependent flow‐mediated vasodilatation ( FMD %) and endothelial‐independent nitroglycerin‐mediated dilatation ( NMD %) in the brachial artery. Results There was a significant impairment of FMD % in patients as compared to controls (mean 8.3% vs . 10.8%, P = 0.007), but there was no significant difference in NMD %. Conclusions There is presence of endothelial dysfunction in patients with PsA independent of risk factors for cardiovascular disease.