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Relationship between adiponectin, leptin, IGF ‐1 and total lipid peroxides plasma concentrations in patients with systemic sclerosis: possible role in disease development
Author(s) -
WinszSzczotka Katarzyna,
KuźnikTrocha Kornelia,
KomosińskaVassev Katarzyna,
Kucharz Eugeniusz,
Kotulska Anna,
Olczyk Krystyna
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12332
Subject(s) - adiponectin , leptin , medicine , adipokine , endocrinology , adipose tissue , erythrocyte sedimentation rate , body mass index , obesity , insulin resistance
Aim The relationship between adiponectin, leptin, insulin‐like growth factor‐1 ( IGF ‐1) and total lipid peroxide ( TLP ) concentrations, and its possible role in the development of diffuse cutaneous systemic sclerosis (dc SS c), were evaluated in this study. Methods, results Plasma adipokines and IGF ‐1 levels were determined using the enzyme‐linked immunosorbent assay method, whereas TLP levels were determined using a photometric test, in 36 dc SS c patients and 40 healthy controls matched by age, sex and body mass index ( BMI ). Plasma levels of adipokines were significantly lowered, while TLP and IGF ‐1 were increased in dc SS c patients compared to controls. Adiponectin correlated significantly with leptin ( r = 0.44), TLP ( r = −0.54), CRP ( r = −0.47), erythrocyte sedimentation rate ( ESR ) ( r = −0.40) and duration of disease ( r = −0.44). A significant relationship was found between leptinemia and IGF ‐1 ( r = −0.40), TLP ( r = 0.44), duration of disease ( r = −0.38) and BMI ( r = 0.65). TLP correlated with IGF ‐1 ( r = −0.43), C‐reactive protein ( r = 0.47), ESR ( r = 0.49) and duration of disease ( r = 0.46), while IGF ‐1 correlated with ESR ( r = −0.40). Conclusions Adipose tissue may play a complex role in the development of dc SS c, affecting both the metabolic state of the organism, as well as free radical‐induced connective tissue degradation. Although, leptin seems to exert a pro‐oxidative effect and both adiponectin and IGF ‐1 appear to prevent free radical damage, confirmation of the above effects requires further research.