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Comparison of plasma vitamin D levels in patients with S jögren's syndrome and healthy subjects
Author(s) -
Erten Şükran,
Şahin Ali,
Altunoğlu Alpaslan,
Gemcioğlu Emin,
Koca Cemile
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12298
Subject(s) - medicine , erythrocyte sedimentation rate , vitamin d and neurology , endocrinology , gastroenterology , vitamin , vitamin d deficiency , autoimmune disease , inflammation , disease
Aim Sjögren's syndrome ( SS ) is a systemic autoimmune disease characterized by chronic inflammation of the salivary and lacrimal glands. There is increasing evidence indicating that vitamin D is important in the initiation and propogation of a range of autoimmune diseases which may include SS . The aim of the present study was to evaluate plasma vitamin D (vit D) levels in patients with SS and to compare this with a control group. Method One hundred and seven SS patients (97 [90.7%] female and 10 [9.3%] male) and 74 healthy controls (64 [86.5%] female and 10 [13.5%] male) were included into the study. Plasma baseline 25‐hydroxy‐vit D levels were measured by high‐powered liquid chromatography method using an Agilent 1100 liquid chromatograph. Results Plasma vit D levels in SS patients (20.5 ± 10.5 μg/L) were significantly lower than in the control group (28.4 ± 15.2 μg/L) ( P < 0.001). Female SS patients had significanly lower vit D levels (19.3 ± 9.3 μg/L) than controls (28.3 ± 15.8 μg/L) ( P < 0.001) but this difference was not present among the male patients and controls. There was no correlation between plasma vit D levels and erythrocyte sedimentation rate and C‐reactive protein in SS patients. Conclusion Vit D deficiency was frequent in patients with SS . In particular, female SS patients had the risk of vit D deficiency. It may be convenient to look for vit D deficiency and to correct vit D nutritional status in SS patients.