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Anxiety and depression in adult patients with familial Mediterranean fever: a study comparing patients living in Germany and Turkey
Author(s) -
Giese Arnd,
Örnek Ahmet,
Kilic Levent,
Kurucay Mustafa,
Şendur Süleyman N.,
Lainka Elke,
Henning Bernhard F.
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12297
Subject(s) - medicine , depression (economics) , hospital anxiety and depression scale , anxiety , familial mediterranean fever , prospective cohort study , disease , psychiatry , economics , macroeconomics
Aim To determine the prevalence of anxiety and depression among patients with familial Mediterranean fever ( FMF ) living in Germany or Turkey a prospective study was conducted. Methods Forty FMF patients living in Turkey (T), 40 FMF patients living in Germany (G) and 40 healthy controls living in Germany (C) were included. Patients and controls were of Turkish ancestry. G were compared to T and C. The Hospital Anxiety and Depression Scale ( HADS ) was used with a cut‐off of ≥ 8 for each subdomain score ( HADS ‐A, HADS ‐D). Results Baseline characteristics of G were comparable to T and C except for age (T: 30.5 years, G: 35.2 years, C: 34.6 years; T vs . G P = 0.045), duration of disease (T: 14.4 years, G: 24; P < 0.001), C‐reactive protein (T: 0.78 mg/dL, G: 0.78 mg/dL, C: 0.35 mg/dL; G vs . C P = 0.03). Prevalence of anxiety was higher in G compared to C (T: 65%, G: 52.5%, C: 22.5%: G vs . C P < 0.05). No difference was found for the prevalence of depression (T: 30%, G: 35%, C: 20%). The association between FMF and anxiety in subjects living in Germany persisted after adjusting for age and gender in a regression analysis and was robust to an adjustment for coexisting depression. Anxiety and depression did not correlate with FMF disease severity assessed with the Pras score. Conclusion Anxiety, but not depression is more common among FMF patients living in Germany compared to healthy controls. No significant difference could be found between FMF patients living in Germany or Turkey concerning the prevalence of anxiety or depression.