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The potential role of angiogenic factors in rheumatoid arthritis
Author(s) -
Azizi Gholamreza,
Boghozian Roobina,
Mirshafiey Abbas
Publication year - 2014
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12280
Subject(s) - angiogenesis , rheumatoid arthritis , medicine , neovascularization , pathogenesis , immunology , arthritis , autoimmunity , transcription factor , cancer research , immune system , biology , gene , genetics
Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as numerous types of tumors and autoimmunity, and also a number of soluble and cell‐bound factors may stimulate neovascularization in inflammatory reaction processes. Here, by highlighting the significance of angiogenesis reaction in rheumatoid arthritis ( RA ), we will mainly focus on the role of various growth factors, cytokines, enzymes, cells, hypoxic conditions and transcription factors in the angiogenic process and we will then explain some therapeutic strategies based on blockage of angiogenesis and modification of the vascular pathology in RA .