Premium
Diagnostic dilemma of paraneoplastic arthritis: case series
Author(s) -
Kisacik Bunyamin,
Onat Ahmet M.,
Kasifoglu Timucin,
Pehlivan Yavuz,
Pamuk Omer N.,
Dalkilic Ediz,
Donmez Salim,
Bilge Sule Y.,
Yilmaz Sedat,
Erdem Hakan,
Mercan Ridvan,
Ozturk Mehmet A.,
Bes Cemal,
Soy Mehmet,
Erten Sukran,
Cobankara Veli,
Senel Soner,
Oner Fatma A.,
Direskeneli Haner,
Yilmaz Sema,
Yazici Ayten,
Emmungil Hakan,
Aksu Kenan,
Kul Seval,
Cetin Gozde Y.,
Sayarlioglu Mehmet
Publication year - 2014
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12277
Subject(s) - medicine , rheumatology , rheumatoid arthritis , polyarthritis , oligoarthritis , arthritis , rheumatoid factor , gastroenterology
Objectives Paraneoplastic arthritis ( PA ) may mimic rheumatic diseases. While presenting the demographic and laboratory features of the patients diagnosed with PA , this study also aims to provide possible appropriate tools to differentiate the PA cases from early rheumatoid arthritis ( ERA ). Methods Sixty‐five patients with PA (male/female: 43/22) from 15 different rheumatology clinics and 50 consecutive patients with ERA (male/female: 13/37) fulfilling the 2010 American College of Rheumatology ( ACR ) criteria for the diagnosis if the RA from Gaziantep Rheumatology Early Arthritis Trial ( GREAT ) as controls who were diagnosed at least 12 months before, were enrolled into study. Results Mean ages of the patients with PA and ERA were 50.2 ± 15.3, and 42.7 ± 12.3, respectively, and the mean ages of the patients with PA were significantly higher than the ERA . Unlike the ERA patients, in our case series PA was predominantly observed among males. Oligoarthritis was significantly higher in solid tumors in contrast to ERA ( P = 0.001). Polyarthritis and symmetric arthritis were significantly higher in the ERA group in contrast to all malignancies ( P = 0.001). Rheumatoid factor ( RF ) and anticyclic citrullinated peptide antibody (anti‐ CCP ) positivity were significantly higher in the ERA group (each P = 0.001). Lactic dehydrogenase levels of hematologic malignancies were significantly higher than other groups (each, P = 0.001). Conclusions ERA patients had more symmetric joint involvement than PA ; laboratory markers could be also an alternative where there is high RF and anti‐ CCP positivity with antibody levels among the ERA patients. Finally, the demographic features can be used as differentiating factors; ERA was seen predominantly among females aged 40–59 years which refers to young adults.