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Association study of human leukocyte antigen‐ DRB 1 alleles with rheumatoid arthritis in Algerian patients
Author(s) -
Djidjik Réda,
Allam Ines,
Douaoui Sanaa,
Meddour Yanis,
Cherguelaîne Khaled,
Tahiat Azzedine,
Raaf Nabil,
Abdessemed Amina,
Khaldoun Naouel,
Bahaz Naima,
Chaib Samia,
LadjouzeRezig Aicha,
Ghaffor Mohamed
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12272
Subject(s) - medicine , rheumatoid arthritis , immunology , human leukocyte antigen , allele , genetic predisposition , rheumatoid factor , antigen , disease , gene , genetics , biology
Rheumatoid arthritis ( RA ) is a chronic, systemic, inflammatory and multifactorial disease. Genetic predisposition seems to play an important role. The aim of this study is to explore the relationship between human leukocyte antigen ( HLA )‐ DRB 1 alleles and susceptibility, clinical and biological features of RA in an Algerian patient population. Methods Using polymerase chain reaction – sequence specific primers ( SSP ), 134 RA patients and 132 healthy controls were genotyped for HLA ‐ DRB 1 and HLA ‐ DRB 1*04 subtypes. Results HLA ‐ DRB 1*04 was found to have increased frequency in the RA group compared to controls ( P < 0.001, OR = 3.14), and was associated with anti‐citrullinated protein antibodies positivity ( ACPA ) ( P = 0.01, OR = 2.35). In contrast, HLA ‐ DRB 1*07 was found to have a decreased frequency in patients compared to controls ( P = 0.003, OR = 0.44) and significant decrease was observed in patients with the rheumatoid factor ( RF ) positivity subgroup ( P = 0.009, OR = 0.29). HLA ‐ DRB 1*04:05 was associated with RA ( P = 0.005, OR = 3.41), whereas, HLA ‐ DRB 1*04:02 showed a protective effect against RA ( P = 0.003, OR = 0.20). Conclusions HLA ‐ DRB 1*04 was associated with increased risk for RA and ACPA positivity, while HLA ‐ DRB 1*07 was associated with reduced risk for RA and RF synthesis in Algerian patients.