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Serum vitamin D level and disease activity in patients with recent onset rheumatoid arthritis
Author(s) -
Zakeri Zahra,
Sandoughi Mahnaz,
Mashhadi Mohammad A.,
Raeesi Vajihollah,
Shahbakhsh Sogol
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12181
Subject(s) - medicine , rheumatoid arthritis , erythrocyte sedimentation rate , rheumatology , rheumatism , vitamin d and neurology , gastroenterology , morning , morning stiffness , psoriatic arthritis
Rheumatoid Arthritis ( RA ) is one of the most prevalent autoimmune diseases. Due to the significance of the relationship between serum vitamin D levels and autoimmune diseases, this study aimed to determine the relationship between serum vitamin D level and the severity of disease activity in patients with newly diagnosed RA . Method This cross‐sectional study was conducted on 66 patients meeting the A merican C ollege of R heumatology – E uropean L eague A gainst R heumatism classification criteria for RA . It was performed in 2012 using simple sampling. The disease activity was measured based on D isease A ctivity S core of 28 joints – erythrocyte sedimentation rate ( DAS 28‐ ESR ) and serum 25‐ OH vitamin D (25( OH ) D ) levels using the chemiluminescent immunoassay method. In addition, the levels of ESR and C ‐reactive protein ( CRP ), the duration of morning stiffness, and the number of joints with tenderness and swollen were calculated as well. The data were analyzed using the P earson correlation coefficient. Results In this study, 10 patients were male (15.2%) and 56 were female (84.8%). The average age of the participants was 45.2 ± 15.3 years. The average level of 25( OH )D in the patients' serum was 30.5 ± 28.9 ng/mL and the mean DAS28‐ESR was 5.6 ± 1.1. The correlation coefficient showed that there was an inverse relationship between 25( OH ) D and DAS 28‐ ESR , the number of tender and swollen joints, global patient assessment and duration of morning stiffness ( P < 0.01). However, the average 25( OH ) D level was not related to ESR ( P = 0.779) and CRP ( P = 0.269). Conclusion The results of this analysis indicated that patients with more active RA have a lower serum vitamin D level.