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Serum Leptin in E gyptian patients with fibromyalgia syndrome: relation to disease severity
Author(s) -
Olama Shereen M.,
ELSAID Tamer O.,
ElArman Mohammad
Publication year - 2013
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12155
Subject(s) - leptin , medicine , fibromyalgia , visual analogue scale , anxiety , beck depression inventory , depression (economics) , body mass index , hamilton anxiety rating scale , endocrinology , physical therapy , gastroenterology , obesity , psychiatry , economics , macroeconomics
Aim Recently, a large body of studies has focused on the leptin levels in psychiatric disorders. This study aimed to measure serum leptin levels in fibromyalgia syndrome ( FMS ) due to a significantly higher prevalence of psychiatric disorder and to determine the relationship between leptin and FMS . Methods The present study was a cross‐sectional descriptive study. Fifty FMS female patients and 50 healthy females serving as a control group were included. Serum samples tested for serum leptin levels were determined by a specific enzyme‐linked immunosorbent assay ( ELISA ). Results Serum leptin levels were significantly lower in FMS patients compared to the control group. The mean serum leptin in patients with FMS was 7.1 ± 6.8 ng/mL compared to 9.4 ± 4.5 ng/mL in the controls (mean difference, −2.48, 95% CI: −4.78, −0.18, P = 0.035). Serum leptin level is inversely correlated with visual analogue scale (VAS) of pain ( P = 0.016), VAS of fatigue ( P = 0.002), VAS of global severity ( P = 0.011), VAS of anxiety ( P = 0.027), global self‐rating index ( P = 0.020), Health Assessment Questionnaire score ( P = 0.016), fibromyalgia impact questionnaire (FIQ) ( P = 0.025), Beck Depression Inventory ( P = 0.002), tender points (TPs) count ( P = 0.041), TPs score ( P = 0.015), and Pittsburg Sleep Quality Index ( P = 0.006). Mean serum leptin levels were also significantly lower in FMS patients with post‐exertion pain ( P = 0.010), depression ( P = 0.029), mood disturbance ( P = 0.018), anxiety ( P = 0.030), short memory difficulties ( P = 0.017), sleep disturbance ( P = 0.028), restless leg syndrome ( P = 0.016), temperomandibular joint syndrome affection ( P = 0.043), palpitation ( P = 0.022), and irritable bowel syndrome ( P = 0.028) than those without. Conclusion We found a significant decrease in serum leptin in FMS patients compared to controls and this decrease correlated with disease severity.