Premium
Plasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patients
Author(s) -
Iwadate Haruyo,
Kobayashi Hiroko,
Kanno Takashi,
Asano Tomoyuki,
Saito Rie,
Sato Shuzo,
Suzuki Eiji,
Watanabe Hiroshi,
Ohira Hiromasa
Publication year - 2014
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12115
Subject(s) - osteopontin , medicine , rheumatoid arthritis , bone resorption , erythrocyte sedimentation rate , endocrinology , n terminal telopeptide , urine , alkaline phosphatase , enzyme , osteocalcin , chemistry , biochemistry
Aim To assess whether any form of osteopontin ( OPN ) is correlated with bone resorption markers or treatment effects in rheumatoid arthritis ( RA ). Method Subjects comprised 119 patients with RA . RA disease activity was evaluated by D isease A ctivity S core ( DAS ) 28, erythrocyte sedimentation rate ( ESR ), and levels of C ‐reactive protein ( CRP ), rheumatoid factor ( RF ) and matrix metalloproteinase ( MMP )‐3. OPN levels in plasma and urine were measured by enzyme‐linked immunosorbent assay ( ELISA ). Levels of tartrate‐resistant acid phosphatase ( TRACP ) 5b in serum and C‐terminal telopeptide of type 1 collagen ( CTX )‐1 in urine were measured by ELISA . Patients were divided into responder and nonresponder groups, and OPN levels were compared at baseline and after treatment. Results Levels of full‐length OPN in plasma ( P ‐ fOPN ) were significantly correlated with levels of TRACP 5b ( r = 0.44, P < 0.001), urine CTX ‐1 ( r = 0.26, P = 0.004) and MMP ‐3 ( r = 0.34, P < 0.001). Levels of TRACP 5b were significantly correlated with age ( r = 0.25, P = 0.007), but levels of P ‐f OPN were not. After treatment, plasma OPN levels were significantly decreased in responders ( P = 0.003). Levels of full‐length or thrombin‐cleaved forms of OPN in urine were not correlated with TRACP 5b or CTX ‐1. Conclusion Our results suggest that plasma OPN may reflect inflammatory bone destruction in RA patients.