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Low body mass index is associated with impaired quality of life in patients with rheumatoid arthritis
Author(s) -
Fukuda Wataru,
Omoto Atsushi,
Ohta Tamaki,
Majima Saori,
Kimura Toshihiro,
Tanaka Toru,
Kohno Masataka,
Kawahito Yutaka
Publication year - 2013
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12079
Subject(s) - medicine , rheumatoid arthritis , body mass index , quality of life (healthcare) , linear regression , gastroenterology , physical therapy , nursing , machine learning , computer science
Aim To investigate the relationship between quality of life ( QOL ) and rheumatoid chachesia, malnutrition in patients with rheumatoid arthritis ( RA ). Methods Euro Q ol G roup 5‐ D imension S elf‐ R eport Q uestionnaire ( EQ 5 D ) and J apanese H ealth A ssessment Q uestionnaire ( JHAQ ) scores, body mass index ( BMI ), arm muscle area ( AMA ) and clinical indicators were measured in 385 RA patients. One‐way analysis of variance for obtained data was conducted among three groups: 131 with low BMI (< 20), 163 with moderate (20–25) and 91 with high BMI (≥25). Then multiple regression analyses for JHAQ and EQ 5 D scores with nutritional and clinical indicators as independent variables were performed. Results EQ 5 D and JHAQ scores were significantly lower and higher, respectively, in the low BMI group than those in the moderate BMI group. Clinical indicators including doses of corticosteroid were similar among the three groups except for disease duration. Disease activity score ( DAS ) 28, disease duration, C ‐reactive protein and AMA were significant variables in the regression model for EQ 5 D . Conclusion Low BMI deteriorates the QOL of RA patients. Muscle protein loss apparently leads to a reduction in BMI and QOL .