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Up regulation of serum tumor necrosis factor‐related apoptosis inducing ligand in juvenile‐onset systemic lupus erythematosus: relations with disease activity, antibodies to double ‐stranded DNA , nephritis and neutropenia
Author(s) -
Ezzat Mohamed H. M.,
ELGammasy Tarek M. A.,
Shaheen Kareem Y. A.,
ELMezdawi Ramzi A. M.,
Youssef Mervat S. M.
Publication year - 2013
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12061
Subject(s) - neutropenia , lupus nephritis , medicine , tumor necrosis factor alpha , apoptosis , antibody , pathogenesis , immunology , receptor , nephritis , cytokine , systemic lupus erythematosus , renal injury , endocrinology , disease , chemistry , kidney , chemotherapy , biochemistry
Objectives Apoptosis is induced by binding of death receptor ligands, members of the tumor necrosis factor ( TNF ) superfamily, to their cognate receptors. It is suggested that TNF ‐related apoptosis inducing ligand ( TRAIL ) is involved in pathogenesis of juvenile‐onset systemic lupus erythematosus ( JSLE ). This study aimed to assess TRAIL concentrations in sera of JSLE children and to determine their potential relationship with disease activity, anti‐double‐stranded DNA (anti‐ds DNA ) levels, neutropenia and renal involvement. Methods Circulating levels of TRAIL were measured by enzyme‐linked immunosorbent assay ( ELISA ) in serum samples obtained from 40 JSLE patients (20 with active and 20 with inactive disease) and 20 controls. Results The mean ( SEM ) serum TRAIL concentration in JSLE was 1750.7 (440.2) pg/mL. Serum TRAIL concentrations in patients were higher than those in controls ( P < 0.01). Serum TRAIL concentrations for children with inactive disease (1854.8 [485.4] pg/mL) and those with activity (1646.6 [390.6] pg/mL) were statistically comparable. JSLE children with positive anti‐ds DNA antibodies had significantly higher TRAIL levels (mean = 1846 [456] vs . 1455 [325] pg/mL; P < 0.05). Serum TRAIL concentrations were significantly higher in classes III and IV nephritis compared to classes I and II nephritis (1970 [512] vs . 1330 [331] pg/mL; P < 0.01). Serum TRAIL concentrations in patients with neutropenia were higher than those without neutropenia (1805 [505] vs . 1516 [400] pg/mL; P = 0.042) and in controls ( P = 0.024). Conclusions Our data indicate that an increased level of TRAIL is a feature of JSLE that correlates with disease activity, anti‐ds DNA titers neutropenia and lupus nephritis.