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The role of bromocriptine in the treatment of patients with active rheumatoid arthritis
Author(s) -
Salesi Mansour,
Sadeghihaddadzavareh Somayeh,
Nasri Peyman,
Namdarigharaghani Nasrin,
Farajzadegan Ziba,
Hajalikhani Mehri
Publication year - 2013
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12015
Subject(s) - medicine , bromocriptine , rheumatoid arthritis , discontinuation , adverse effect , placebo , nausea , methotrexate , arthritis , prolactin , hormone , alternative medicine , pathology
Aim We decided to determine the effectiveness of oral bromocriptine in patients with active rheumatoid arthritis ( RA ) who are in methotrexate ( MTX ) therapy. Methods Patients receiving stable doses of MTX were randomized to one of two groups and received 3 months of double‐blind bromocriptine (5 mg/day) or matching placebo. The moderate and major outcome measures were the proportion of patients with > 0.6 and > 1.2 improvement in RA based on the Disease Activity Score 28 ( DAS 28) at 3 months. Safety measures included adverse events and laboratory assessments. Results On a background treatment of MTX , the percentage of patients with moderate and major DAS 28 responses at 3 months in the bromocriptine group (73.8%/59.5%) was not significantly different from placebo (63.1%/31.6%). Side effects were typically mild and included mild nausea and sleep disturbance; we did not have any adverse events resulting in discontinuation of the study drug. Conclusion In patients with active RA receiving stable doses of MTX , bromocriptine showed non‐significant improvement in efficiency outcomes compared to placebo.