Open AccessPrevalence of in‐hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
Author(s) -
Alvarez Paulino A.,
Putney David,
Ogunti Richard,
Puppala Mamta,
Ganduglia Cecilia,
TorreAmione Guillermo,
Schutt Robert,
Wong Stephen T. C.,
Estep Jerry D.
Publication year - 2017
Publication title -
cardiovascular therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 46
eISSN - 1755-5922
pISSN - 1755-5914
DOI - 10.1111/1755-5922.12256
Subject(s) - medicine , heart failure , renal function , nonsteroidal , adverse effect , cohort , mortality rate , drug , psychiatry
Summary Aim To determine the prevalence of in‐hospital nonsteroidal antiinflammatory drug (NSAID) exposure and associated outcomes in patients admitted with a primary diagnosis of heart failure. Methods We performed a propensity‐matched cohort analysis of patients admitted to Houston Methodist Hospital System with a primary diagnosis of heart failure according to the International Classification of Diseases‐9‐Clinical Modification (ICD‐9‐CM) from January 1, 2011 to December 31, 2014. Results Of the 9742 patients admitted with a primary diagnosis of heart failure, 384 patients (3.9%) were exposed to NSAID. After applying propensity scores we matched 305 NSAID exposed with 915 unexposed patients. Patients with in‐hospital NSAID exposure had a longer length of stay (7.0±8.8 days vs 6.1±8.5; P =.003) and increased prevalence of worsening renal function (34.4% vs 27.9%; P =.030). There were not statically significant differences in in‐hospital mortality rate or 30‐day all‐cause readmission rate. Conclusion Exposure to NSAID in patients admitted with a primary diagnosis of heart failure was low but was associated with adverse outcomes including longer length of stay and higher prevalence or worsening renal function.