Open AccessImpact of High Loading Dose of Atorvastatin in Diabetic Patients with Renal Dysfunction Undergoing Elective Percutaneous Coronary Intervention: A Randomized Controlled Trial
Author(s) -
Shehata Mohamed,
Hamza Mohamed
Publication year - 2015
Publication title -
cardiovascular therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 46
eISSN - 1755-5922
pISSN - 1755-5914
DOI - 10.1111/1755-5922.12108
Subject(s) - medicine , atorvastatin , renal function , percutaneous coronary intervention , creatinine , kidney disease , placebo , conventional pci , urology , contrast induced nephropathy , randomized controlled trial , incidence (geometry) , nephropathy , gastroenterology , diabetes mellitus , surgery , myocardial infarction , endocrinology , physics , alternative medicine , pathology , optics
Summary Introduction The effectiveness of statin pretreatment in reducing the incidence of contrast‐induced nephropathy (CIN) has been examined in some observational and randomized studies, yielding controversial results. Aim This study sought to evaluate the role of atorvastatin in prevention of CIN in diabetic patients with mild‐to‐moderate chronic kidney disease ( CKD ), undergoing elective percutaneous coronary intervention (PCI). Methods 130 patients with mean glomerular filtration rate of 48.5 ± 16 mL/min/1.73 m were prospectively enrolled, then randomly (double blind) assigned in 1:1 ratio to receive atorvastatin (80 mg daily for 48 h) or placebo. Serum creatinine and glomerular filtration rate were measured preintervention, 72 h and 10 days thereafter. An increase in serum creatinine by >0.5 mg/dL (44.2 μ mol/L) or >25% of baseline value was considered as CIN . Results Mean age of the study cohort was 56 ± 5 years (males: 62%). Mean serum creatinine level in the placebo group increased significantly 3 days after coronary intervention and declined on the 10th day to a level that did not differ significantly from the baseline level, but still higher. However, in atorvastatin group, mean serum creatinine level showed a nonsignificant rise on the third day and then decreased to a level close to the baseline one, on the 10th day. Incidence of CIN was 7.7% in atorvastatin group and 20% in the placebo group ( P < 0.05). Conclusion Atorvastatin dose of 80 mg per day for 48 h is associated with decreased incidence of CIN in diabetic patients with CKD undergoing PCI .