Open AccessDiabetes Mellitus and Atrial Remodeling: Mechanisms and Potential Upstream Therapies
Author(s) -
Zhang Qitong,
Liu Tong,
Ng Chee Y.,
Li Guangping
Publication year - 2014
Publication title -
cardiovascular therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 46
eISSN - 1755-5922
pISSN - 1755-5914
DOI - 10.1111/1755-5922.12089
Subject(s) - medicine , diabetes mellitus , atrial fibrillation , cardiology , clinical trial , endocrinology
Summary Atrial fibrillation ( AF ) is the most common cardiac arrhythmia in clinical practice, and its prevalence has increasing substantially over the last decades. Recent data suggest that there is an increased risk of AF among the patients with diabetes mellitus ( DM ). However, the potential molecular mechanisms regarding DM ‐related AF and diabetic atrial remodeling are not fully understood. In this comprehensive review, we would like to summarize the potential relationship between diabetes and atrial remodeling, including structural, electrical, and autonomic remodeling. Also, some upstream therapies, such as thiazolidinediones, probucol, ACEI / ARB s, may play an important role in the prevention and treatment of AF . Therefore, large prospective randomized, controlled trials and further experimental studies should be challengingly continued.