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Alternative volumetric PET parameters for evaluation of breast cancer cases with 18F‐FDG PET/CT imaging: Metabolic tumour volume and total lesion glycolysis
Author(s) -
Arslan Esra,
Can Trabulus Didem,
Mermut Özlem,
Şavlı Taha Cumhan,
Çermik Tevfik Fikret
Publication year - 2021
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.13114
Subject(s) - medicine , breast cancer , standardized uptake value , nuclear medicine , metastasis , positron emission tomography , lymph node , cancer , radiology , pathology
We aimed to investigate the prognostic and clinical values of two volumetric PET parameters used in conjunction with SUV max at different thresholds in invasive ductal carcinoma (IDC). Methods A total of 139 metastatic IDC BC who underwent 18F‐FDG PET/CT imaging were included to study. MTV and TLG (40%, 50%, 60% and 70%) used in conjunction with primary tumour SUV max . Nodal involvement, distant metastasis, ER, PR, Ki‐67 expression and survival data evaluated by comparing FDG PET parameters. Results Mean ± SD SUV max of lesions ( n = 139) was 13.97 ± 9.21. Primary tumour 18F‐FDG uptake associated increased tumour diameter (>2 cm), high Ki‐67 (>15%) and distant organ metastasis (DOM) ( P = 0.015, 0.005 and 0.016, respectively). There was significant association between molecular subtypes and SUV max ( P = 0.002). High MTV associated with tumour diameter (MTV 40–70%), axillary lymph node (ALN) diameter (MTV 40–70%), and distant nodal metastasis (DNM) (MTV 50–70%). High TLG associated with tumour diameter (TLG 40–70%), high Ki‐67 (TLG 40–70%), ALN metastasis (TLG 40%), ALN diameter (TLG 40–70%) and DNM (TLG 40–70%). Median survival found shorter in DOM patients ( P = 0.030, Log Rank = 0.110). Conclusion We think evaluation of MTV and TLG at different thresholds in addition to SUV max would enhance diagnostic and prognostic value of 18F‐FDG PET/CT, and thus contribute to disease management.