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High‐grade Glioma – A decade of care in Christchurch
Author(s) -
Yan Shan Shan,
James Melissa L,
Kerstens Peter,
Lambert Megan,
Robinson Bridget A,
Yi Ma
Publication year - 2019
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12944
Subject(s) - medicine , glioma , multivariate analysis , neurosurgery , radiation therapy , retrospective cohort study , survival analysis , biopsy , overall survival , glioblastoma , oncology , surgery , cancer research
High‐grade glioma (HGG) is a devastating illness. Our study aimed to investigate outcomes for patients with HGG treated in Christchurch focussing particularly on those diagnosed with glioblastoma mulitforme (GBM); compare GBM survival with international standards; examine factors associated with better prognosis; and assess the involvement of various allied health disciplines. Methods A 10‐year retrospective study of patients who were diagnosed and treated for HGG at Christchurch Hospital. Kaplan–Meier method was used to estimate survival. Predefined multivariate analysis was performed to investigate potential prognostic and predictive factors. Results A total of 363 patients were diagnosed with HGG at a median age of 64 years with a 5‐year overall survival of 6.1%. Patients with grade IV tumours had a poorer outcome than grade III patients ( P = 0.0002, log‐rank test). Eighty‐two per cent of patients had a surgical resection or biopsy of the tumour. For those patients with GBM, gross tumour resection followed by radical chemoradiation was associated with better survival compared with needle biopsy (HR = 1.93, P = 0.018); increasing age was negatively associated with survival (HR = 1.02 per additional age year, P = 0.037); however, waiting time between neurosurgery and radiation did not affect survival. Six per cent of patients received formal psychological input. Conclusion Our survival outcomes were comparable with internationally published series. More research is required to improve survival in HGG, including molecular guided treatment, and better define treatment paradigms, such as for the elderly and frail.