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Utility of 18F‐fluorodeoxyglucose‐positron emission tomography in the differential diagnosis of benign and malignant gynaecological tumours
Author(s) -
Takagi Hiroaki,
Sakamoto Jinichi,
Osaka Yasuhiro,
Shibata Takeo,
Fujita Satoko,
Sasagawa Toshiyuki
Publication year - 2018
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12707
Subject(s) - medicine , receiver operating characteristic , differential diagnosis , positron emission tomography , standardized uptake value , fluorodeoxyglucose , confidence interval , area under the curve , radiology , nuclear medicine , ovarian cancer , cancer , pathology
Positron emission tomography/computed tomography ( PET / CT ) involving 18F‐fluorodeoxyglucose ( FDG ) is widely used for systemic cancer and recurrence diagnosis. However, the differential diagnosis of benign and malignant gynaecological tumours according to FDG accumulation is unclear. This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. Methods This study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F‐ FDG PET / CT . We assessed the maximum standardized uptake value ( SUV max) and determined its utility in the diagnosis of benign and malignant tumours using a receiver operating characteristic ( ROC ) curve analysis. Results Among the 63 patients with ovarian tumours, the mean SUV max of 22 patients with benign ovarian tumours was 2.48 and the mean SUV max of 41 patients with malignant ovarian tumours was 10.98 ( P < 0.001). In the ROC curve analysis, the area under the curve ( AUC ) was 0.977, with a 95% confidence interval of 0.947–1.000. With a cut‐off value of 3.97 for the optimal SUV max, the sensitivity and specificity were 95.1% and 86.4%, respectively. In addition, the AUC was 0.911 (95% CI : 0.768–1.000) for the assessment of uterine myomas and sarcomas. With a cut‐off value of 10.62 for the optimal SUV max, the sensitivity and specificity were 91.7% and 86.7% respectively. Conclusions The SUV max value helps differentiate benign and malignant ovarian tumours, as well as uterine myomas and uterine sarcomas.