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Morphologically ‘invisible’ proinsulin – secreting adenoma detected by Ga‐68 Exendin‐4 ( GLP ‐1 Receptor) positron emission tomography/ CT
Author(s) -
Werner Christoph,
Lupp Amelie,
Drescher Robert,
Freesmeyer Martin,
Mireskandari Masoud,
Stoykow Christian,
Bauschke Astrid,
Müller Ulrich A
Publication year - 2018
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12704
Subject(s) - medicine , proinsulin , malignancy , positron emission tomography , lesion , neuroendocrine tumour , insulinoma , adenoma , receptor , nuclear medicine , pathology , pancreas , insulin
Summary This case report of a young man suffering from recurring hypoglycaemia illustrates a rare condition of a neuroendocrine tumour, predominantly secreting proinsulin and invisible to conventional imaging approaches. Only a GLP ‐1 receptor PET / CT using Exendin‐4 visualized the pancreatic lesion and enabled curative therapy, confirming the diagnostic value of this tracer for detection of neuroendocrine tumours. As only few publications on this topic are available, an overview of the available data is also given. The known cut‐off value of 60% for proinsulin level indicating malignancy is critically discussed.