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Correlation of dynamic contrast‐enhanced MRI derived volume transfer constant with histological angiogenic markers in high‐grade gliomas
Author(s) -
Di Ningning,
Yao Chenjun,
Cheng Wenna,
Ren Yan,
Qu Jianxun,
Wang Bin,
Yao Zhenwei
Publication year - 2018
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12701
Subject(s) - medicine , angiogenesis , cd34 , magnetic resonance imaging , pathology , biopsy , dynamic contrast , vascular endothelial growth factor , immunohistochemistry , glioma , dynamic contrast enhanced mri , correlation , vegf receptors , nuclear medicine , radiology , stem cell , cancer research , biology , geometry , mathematics , genetics
To ascertain if the volume transfer constant ( K trans ) derived from T1 dynamic contrast‐enhanced magnetic resonance imaging ( DCE ‐ MRI ) correlates with the immunohistological markers of angiogenesis in high‐grade gliomas. Methods Fifty‐one image‐guided biopsy specimens in 34 patients with newly presenting high‐grade gliomas (grade III = 16; grade IV = 18) underwent preoperative imaging (conventional imaging and T1 DCE ‐ MRI ). We correlated vascular endothelial growth factor ( VEGF ) expression and the microvessel density ( MVD ) of MRI ‐guided biopsy specimens with the corresponding DCE ‐derived K trans . Histological sections were stained with VEGF and CD 34, and examined under light microscopy. These histological and molecular markers of angiogenesis were correlated with the K trans of the region of interest corresponding to the biopsy specimen. Results The K trans showed a significant positive correlation with VEGF expression ( ρ = 0.582, P = 0.001) but not with MVD stained with CD 34 antibody ( ρ = 0.328, P = 0.072). Conclusion The K trans derived from DCE ‐ MRI can reflect the VEGF expression of high‐grade gliomas but not the MVD .