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‘Compromise position’ image alignment to accommodate independent motion of multiple clinical target volumes during radiotherapy: A high risk prostate cancer example
Author(s) -
Rosewall Tara,
Yan Jing,
Alasti Hamideh,
Cerase Carla,
Bayley Andrew
Publication year - 2017
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12543
Subject(s) - medicine , prostate cancer , compromise , prostate , residual , nuclear medicine , cancer , algorithm , computer science , social science , sociology
Inclusion of multiple independently moving clinical target volumes ( CTV s) in the irradiated volume causes an image guidance conundrum. The purpose of this research was to use high risk prostate cancer as a clinical example to evaluate a ‘compromise’ image alignment strategy. Methods The daily pre‐treatment orthogonal EPI for 14 consecutive patients were included in this analysis. Image matching was performed by aligning to the prostate only, the bony pelvis only and using the ‘compromise’ strategy. Residual CTV surrogate displacements were quantified for each of the alignment strategies. Results Analysis of the 388 daily fractions indicated surrogate displacements were well‐correlated in all directions ( r 2 = 0.95 ( LR ), 0.67 ( AP ) and 0.59 ( SI ). Differences between the surrogates displacements (95% range) were −0.4 to 1.8 mm ( LR ), −1.2 to 5.2 mm ( SI ) and −1.2 to 5.2 mm ( AP ). The distribution of the residual displacements was significantly smaller using the ‘compromise’ strategy, compared to the other strategies (p 0.005). The ‘compromise’ strategy ensured the CTV was encompassed by the PTV in all fractions, compared to 47 PTV violations when aligned to prostate only. Conclusions This study demonstrated the feasibility of a compromise position image guidance strategy to accommodate simultaneous displacements of two independently moving CTV s. Application of this strategy was facilitated by correlation between the CTV displacements and resulted in no geometric excursions of the CTV s beyond standard sized PTV s. This simple image guidance strategy may also be applicable to other disease sites that concurrently irradiate multiple CTV s, such as head and neck, lung and cervix cancer.