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Role of radiation in the treatment of non‐metastatic osseous E wing sarcoma
Author(s) -
Ning Matthew S,
Perkins Stephanie M,
Borinstein Scott C,
Holt Ginger E,
Stavas Mark J,
Shinohara Eric T
Publication year - 2016
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12389
Subject(s) - medicine , sarcoma , wing , radiation therapy , cancer research , oncology , radiology , pathology , engineering , aerospace engineering
Local control, either with surgery, radiation ( RT ) or both, is essential in the management of localised E wing sarcoma; however, the relative role of RT remains controversial. Methods Using the S urveillance, E pidemiology, and E nd R esults database, 612 patients treated for non‐metastatic skeletal Ewing sarcoma between the years 1988 and 2010 were identified. Results Median age and follow‐up were 13 years (range: 0–21) and 56 months (range: 0–287), respectively. Five‐year overall survival ( OS ) for the cohort was 74.4 ± 2.0%. Patients received surgery alone (51.3%), RT alone (21.6%) or both (27.1%). Patients with skeletal E wing sarcoma had improved OS with surgery alone compared with other treatments. However, in subset analyses, RT was not inferior to surgery alone for appendicular (5‐year OS : 80.0% vs. 79.3%), non‐pelvic (84.3% vs. 79.9%) or localised disease (confined to cortex or periosteum; 79.7% vs. 80.6%). After controlling for stage and site, no increase in mortality was observed with RT versus surgery alone (hazard ratio = 0.77 (95% confidence interval: 0.49–1.19)). Conclusions I n regard to survival, RT did not appear to be inferior to surgery alone for most patients, particularly those with disease at favourable sites (localised, appendicular, non‐pelvic). In select patients with E wing sarcoma, RT may be an appropriate strategy for local control that does not necessarily compromise survival outcomes.