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Assessment of pancreatic adenocarcinoma: Use of low‐dose whole pancreatic CT perfusion and individualized dual‐energy CT scanning
Author(s) -
Li Haiou,
Guo Jun,
Sun Cong,
Li Xiao,
Qi Yaodong,
Wang Ximing,
Xu Zhuodong,
Chen Jiuhong,
Liu Cheng
Publication year - 2015
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12342
Subject(s) - medicine , perfusion , adenocarcinoma , pancreas , nuclear medicine , radiology , pancreatic cancer , parenchyma , perfusion scanning , pancreatic disease , pathology , cancer
The objective of this study was to investigate the value of low‐dose whole pancreatic computed tomography ( CT ) perfusion integrated with individualized dual‐energy CT ( DECT ) scanning in the diagnosis of pancreatic adenocarcinoma. Methods Twenty patients with pancreatic adenocarcinoma underwent pancreatic CT perfusion as well as individualized dual‐phase DECT pancreatic scans. Perfusion characteristics of non‐tumourous pancreatic parenchyma and pancreatic adenocarcinoma were analysed. Weighted‐average 120 kVp images and the optimal monoenergetic images in dual phase were reconstructed and the contrast noise ratio ( CNR ) of pancreas‐to‐tumour were compared. Results There were significant difference on blood flow as well as blood volume between pancreatic adenocarcinoma and the non‐tumourous pancreatic parenchyma ( P < 0.05), whereas no difference on permeability ( P > 0.05). CNRs of pancreas‐to‐tumour in individualized pancreatic phase were significantly higher than those in venous phase ( P < 0.05), and CNRs of optimal monoenergetic images were higher than those on weighted‐average 120 kVp images ( P < 0.05) in both phase. Total effective radiation dose of CT examination was around 9.32–13.75 mSv . Conclusions Low‐dose whole pancreatic CT perfusion can provide functional information, and the individualized pancreatic phase DECT scan is the optimal method for detecting pancreatic adenocarcinomas. The integration of the two techniques has great value in clinical application.