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The diagnostic value of diffusion‐weighted imaging and the apparent diffusion coefficient values in the differentiation of benign and malignant breast lesions
Author(s) -
Çabuk Gonca,
Nass Duce Meltem,
Özgür Anıl,
Apaydın Feramuz Demir,
Polat Ayşe,
Orekici Gülhan
Publication year - 2015
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12273
Subject(s) - medicine , effective diffusion coefficient , nuclear medicine , diffusion mri , mann–whitney u test , receiver operating characteristic , echo planar imaging , radiology , magnetic resonance imaging
The goal of our study was to evaluate the diagnostic efficacy of diffusion‐weighted imaging ( DWI ) in the differentiation of benign and malignant breast lesions. Methods Between J une 2012 and M arch 2013, 60 patients with 63 lesions (age range 29–70 years, mean age 48.6 years) were included in our study. All lesions, except complicated cysts and intra‐mammary lymph nodes, were confirmed histopathologically. The patients were evaluated with a 1.5 T esla MR scanner using dedicated bilateral breast coil. DWI images were obtained by echo planar imaging sequence and ‘b’ values were selected as 200, 600 and 1000 s/mm 2 . Apparent diffusion coefficient ( ADC ) values of both breast lesions and the normal fibroglandular tissue of the contralateral breast were calculated and statistically compared using S hapiro– W ilk test, S tudent's t ‐test, M ann– W hitney U test, chi‐square test and the receiver operating curve. Results Of 63 lesions, 22 were malignant and 41 were benign. In malignant lesions, the mean ADC values were 1.40 ± 0.41 × 10 −3 mm 2 /s for b = 200, 1.05 ± 0.28 × 10 −3 mm 2 /s for b = 600 and 0.91 ± 0.20 × 10 −3 mm 2 /s for b = 1000 and in benign lesions, the mean ADC values were 2.13 ± 0.85 × 10 −3 mm 2 /s for b = 200, 1.64 ± 0.47 × 10 −3 mm 2 /s for b = 600 and 1.40 ± 0.43 × 10 −3 mm 2 /s for b = 1000. The success of ADC values in differentiation of benign and malignant lesions was statistically significant ( P = 0.0001). The threshold values were determined to be 1.50 × 10 −3 mm 2 /s for b = 200, 1.22 × 10 −3 mm 2 /s for b = 600 and 0.98 × 10 −3 mm 2 /s for b = 1000 ( P < 0.05). Conclusion DWI can be an effective radiological method in the differentiation of benign and malignant breast lesions.