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Sensitivity of patients with familial cerebral cavernous malformations to therapeutic radiation
Author(s) -
Golden Michael,
Saeidi Saba,
Liem Benny,
Marchand Eric,
Morrison Leslie,
Hart Blaine
Publication year - 2015
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12269
Subject(s) - medicine , cavernous malformations , congenital malformations , disease , lesion , mechanism (biology) , radiation sensitivity , radiation exposure , radiology , pediatrics , pathology , nuclear medicine , irradiation , pregnancy , genetics , philosophy , physics , epistemology , biology , nuclear physics
Summary Familial cerebral cavernous malformations are autosomal dominant conditions that can result in significant morbidity. A two‐hit mechanism is accepted as likely responsible for formation of these malformations. We present two patients with this disease who received therapeutic radiation and developed very high numbers of malformations within the radiation ports, supporting radiation as an accelerator of lesion formation and suggesting implications for risks of radiation in this disease.