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Meta‐analysis of diagnosis of liver metastatic cancers: Comparison of 18 FDG PET ‐ CT and gadolinium‐enhanced MRI
Author(s) -
Deng Jinlong,
Tang Jiande,
Shen Naipeng
Publication year - 2014
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12231
Subject(s) - medicine , gadolinium , nuclear medicine , positron emission tomography , receiver operating characteristic , magnetic resonance imaging , radiology , meta analysis , likelihood ratios in diagnostic testing , pathology , materials science , metallurgy
We performed a meta‐analysis to compare the performance of 18F‐fluorodeoxyglucose ( 18 FDG ) positron emission tomography‐CT ( PET ‐ CT ) with that of gadolinium‐enhanced MRI for the detection of liver metastatic cancers. Methods The MEDLINE and EMBASE databases were searched for relevant original articles. The histology and/or imaging follow‐up data served as the reference standard. We calculated the pooled sensitivities, specificities, positive likelihood ratios, negative likelihood ratios and constructed summary receiver operating characteristic curves for 18 FDG PET ‐ CT and gadolinium‐enhanced MRI , respectively. Results Ten studies (1105 patients) were included for this meta‐analysis. 18 FDG PET ‐ CT has similar patient‐based specificity (1.00 and 0.99), positive likelihood ratios (253.1 and 138.2), negative likelihood ratios (0.16 and 0.10) and area under curves (0.99 and 0.99) with gadolinium‐enhanced MRI . G adolinium‐enhanced MRI tends to have higher sensitivity (0.91 and 0.84) than 18 FDG PET ‐ CT . Conclusion Both 18 FDG PET ‐ CT and gadolinium‐enhanced MRI have excellent diagnostic performance for the detection of liver metastatic cancer.