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Correlation of quantitative diffusion‐weighted and dynamic contrast‐enhanced MRI parameters with prognostic factors in prostate cancer
Author(s) -
Chung Melody P.,
Margolis Dan,
Mesko Shane,
Wang Jason,
Kupelian Patrick,
Kamrava Mitchell
Publication year - 2014
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12230
Subject(s) - medicine , prostate cancer , effective diffusion coefficient , prostate , multiparametric mri , diffusion mri , stage (stratigraphy) , prostate specific antigen , magnetic resonance imaging , cancer , nuclear medicine , receiver operating characteristic , area under the curve , oncology , radiology , paleontology , biology
The aim of this study was to determine if correlations exist between quantitative parameters from dynamic contrast‐enhanced ( DCE ) and diffusion‐weighted ( DW ) MRI with N ational C omprehensive C ancer N etwork ( NCCN ) risk group, G leason score ( GS ), maximum tumour diameter ( MTD ), pre‐treatment prostate‐specific antigen ( PSA ), clinical T stage and MRI prostate volume in prostate cancer. Method We retrospectively reviewed 3 T multiparametric MRI reports on biopsy‐proven prostate cancer patients performed during radiation treatment evaluation or an active surveillance protocol. DCE ‐ MRI parameters included K trans (influx volume transfer coefficient), K ep (efflux reflux rate constant) and iAUC (initial area under the curve). Average DCE and apparent diffusion coefficient ( ADC ) values were recorded for regions of interest on DW ‐ MRI . Relationships between MRI metrics and risk group, GS , MTD , PSA , clinical T stage and MRI prostate volume were examined using analysis of variance. Central and peripheral tumours were also analysed separately in a sub‐analysis. Statistical significance was defined as P < 0.0125. Results Of 58 patients, 29%, 52% and 19% had low ( L ), intermediate ( I ), or high ( H ) NCCN risk disease, respectively. K trans significantly correlated with PSA . For central tumours, K trans significantly correlated with MTD and PSA , and K ep significantly correlated with PSA . For peripheral tumours, iAUC was significantly different when stratified by L / I / H risk and GS , and ADC score with L / I / H risk, GS , and clinical T stage. Conclusions DCE ‐ and DW ‐ MRI metrics correlate with some risk stratification factors in prostate cancer. Further work is required to determine if MRI metrics are complementary or independent prognostic factors.