Premium
Dosimetric and radiobiologic comparison of 3 D conformal, IMRT , VMAT and proton therapy for the treatment of early‐stage glottic cancer
Author(s) -
Matthiesen Chance,
Herman Tania De La Fuente,
Singh Hardev,
Mascia Anthony,
Confer Michael,
Simpson Hilarie,
Higby Christine,
Arain Abeer,
Keole Sameer,
Herman Terence,
Bogardus Carl,
Zhao Yan D.,
Ahmad Salahuddin
Publication year - 2015
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12227
Subject(s) - medicine , nuclear medicine , radiation therapy , proton therapy , radiation treatment planning , stage (stratigraphy) , radiology , paleontology , biology
Background This study aims to compare dosimetrically and radiobiologically 3 D conformal, intensity modulated radiation therapy ( IMRT ), RapidArc ( RA ) volumetric modulated arc therapy and proton therapy techniques for early‐stage glottic cancer. Methods Ten patients were retrospectively selected. Photon treatment planning was performed using Eclipse External Beam Planning, and proton planning was performed using CMS Xio. The minimum, mean and maximum dose values for planning target volume ( PTV ), mean and maximum dose values for organ at risk, % of volume of PTV receiving at least 95% of the prescription dose, and D 20, D 50 and D 90 of carotid arteries were compared. Biological response models of tumour control probabilities and normal tissue complication probabilities were calculated. Results IMRT , RA and proton plans versus three‐dimensional conformal radiotherapy (3 D‐CRT ) plans consistently provided superior PTV coverage and decreased mean dose to the thyroid and carotid arteries. Conclusion All these three modalities showed superiority with less variation among themselves compared with 3 D‐CRT plans. Clinical investigation is warranted to determine if these treatment approaches will translate into a reduction in radiation therapy‐induced toxicities.