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Radiotherapy in fascial fibromatosis: A case series, literature review and considerations for treatment of early‐stage disease
Author(s) -
Grenfell Solveig,
Borg Martin
Publication year - 2014
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/1754-9485.12178
Subject(s) - medicine , radiation therapy , stage (stratigraphy) , fibromatosis , aggressive fibromatosis , disease , fascia , surgery , dermatology , paleontology , biology
Palmar and plantar fascial fibromatoses are benign hyperproliferative disorders of the deep fascia of the palm and sole. This study seeks to examine the role of radiotherapy in the management of fascial fibromatosis. Method Six consecutive cases of early‐stage fascial fibromatosis treated with radiotherapy at the A delaide R adiotherapy C entre between J uly 2008 and M ay 2011 were analysed. The results of the case series were compared with a systematic review of the literature. Results All six cases regressed or showed a reduction of symptoms following radiotherapy. Treatment was well tolerated with minor toxicities. Median follow‐up for the case series was 38.5 months. The systematic review identified seven studies describing the use of radiotherapy as primary treatment for fascial fibromatosis between 1946 and 2013. The literature indicates that radiotherapy can prevent disease progression and improve symptoms for early‐stage disease, with low likelihood of significant toxicities. Conclusion Early results from our case series are consistent with the literature, showing that radiotherapy can provide an effective management option for patients with early‐stage fascial fibromatosis, and justify consideration of radiotherapy as a primary treatment for early‐stage disease.