Open AccessIntussusception in Australia: epidemiology prior to the introduction of rotavirus vaccine
Author(s) -
PalupiBaroto Retno,
Lee Katherine J.,
Carlin John B.,
Bines Julie E.
Publication year - 2015
Publication title -
australian and new zealand journal of public health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.946
H-Index - 76
eISSN - 1753-6405
pISSN - 1326-0200
DOI - 10.1111/1753-6405.12297
Subject(s) - intussusception (medical disorder) , medicine , rotavirus vaccine , rotavirus , incidence (geometry) , epidemiology , logistic regression , pediatrics , proxy (statistics) , population , vaccination , demography , rotavirus gastroenteritis , surgery , environmental health , immunology , diarrhea , machine learning , sociology , computer science , optics , physics
Objectives: To describe the incidence rate and clinical outcomes of intussusception in Australia in children aged <24 months prior to the use of rotavirus vaccines in Australia, and to explore associations between patient characteristics and outcomes in children with intussusception. Methods: This study used Australian national hospital discharge data on intussusception from July 2000 to June 2006 for children aged <24 months and data from the Australian Bureau of Statistics (ABS) as a proxy for population numbers to estimate incidence. Logistic regression was used to examine associations between patient characteristics (age, sex, ethnicity) and outcomes (length of hospital stay >2 days and the need for surgical intervention). Results: The overall incidence rate of intussusception was 5.4 per 10,000 child‐years in children under 24 months (95%CI 5.17–5.70). There was a declining rate over the study period ( p <0.001). Age at time of intussusception was strongly associated with length of hospital stay and surgery. Conclusions: This study provides an estimate of the pre‐rotavirus vaccine incidence of intussusception across Australia, which is important for monitoring the occurrence of intussusceptions post the introduction of rotavirus vaccine.