Open AccessmiRNAs 作为2型糖尿病诊断生物标志物的系统评价
Author(s) -
GonzálezSánchez Luis Edgar,
OrtegaCamarillo Clara,
ContrerasRamos Alejandra,
BarajasNava Leticia Andrea
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13166
Subject(s) - prediabetes , medicine , cinahl , microrna , type 2 diabetes , diabetes mellitus , population , bioinformatics , endocrinology , genetics , biology , gene , environmental health , psychiatry , psychological intervention
Background This systematic review summarizes results of studies that evaluated the expression of microRNAs (miRs) in prediabetes or type 2 diabetes (T2D). Methods The information was obtained from PubMed, EMBL‐EBI, Wanfang, Trip Database, Lilacs, CINAHL, Human microRNA Disease Database (HMDD) v3.0, and Google. A qualitative synthesis of the results was performed and miRs frequency was graphically represented. From 1893 identified studies, only 55 fulfilled the inclusion criteria. These 55 studies analyzed miRs in T2D, and of them, 13 also described data of prediabetes. Results In diabetics, 122 miRs were reported and 35 miRs for prediabetics. However, we identified that five miRs (‐122‐5p, 144‐3p, 210, 375, and ‐126b) were reported more often in diabetics and four (144‐3p, ‐192, 29a, and ‐30d) in prediabetics. Conclusions Circulating miRs could be used as biomarkers of T2D. However, it is necessary to validate these microRNAs in prospective and multicenter studies with different population subgroups, considering age, gender, and risk factors.