Open AccessCOVID‐19患者的代谢综合征和临床结局:代谢综合征患者的年龄、性别和种族重要吗?
Author(s) -
Lohia Prateek,
Kapur Shweta,
Benjaram Sindhuri,
Pandey Abhilasha,
Mir Tanveer,
Seyoum Berhane
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13157
Subject(s) - medicine , interquartile range , intensive care unit , body mass index , metabolic syndrome , odds ratio , diabetes mellitus , mechanical ventilation , retrospective cohort study , obesity , comorbidity , cohort , endocrinology
Background Metabolic syndrome (MetS) is highly prevalent worldwide, and its individual components obesity, diabetes, and hypertension have been identified as risk factors to develop severe coronavirus disease 2019 (COVID‐19); however, data on MetS and clinical outcomes in COVID‐19 are scarce. This study aims to determine association between MetS and severe disease outcomes, that is, mortality, need for mechanical ventilation, and intensive care unit (ICU) requirement among patients with COVID‐19. Methods This is a retrospective multihospital cohort study on 1871 patients with confirmed COVID‐19 diagnosis. Patient data including demographics, comorbidities, body mass index (BMI), smoking, laboratory data, and the clinical course of hospitalization were collected. Multivariable regression was performed adjusting for age, sex, race, insurance, smoking, and comorbidities. Results A total of 1871 patients (median age 66 [interquartile range, IQR 54‐75]; 965 (51.6%) males; 1494 (80%) African Americans; median BMI 29.4 kg/m 2 [IQR 25‐35.8]; 573 (30.6%) patients with MetS) were included. Patients with MetS had increased mortality (odds ratio [OR], 1.40; 95% CI, 1.11‐1.75; P = .004), higher ICU admission (OR, 1.68; 95% CI, 1.36‐2.08; P < .001), and increased need for mechanical ventilation (OR, 1.90; 95% CI, 1.52‐2.37; P < .001). Among individual comorbidities, diabetes had significant association with mortality (OR, 1.30; 95% CI, 1.05‐1.63; P = 0.02), ICU admission (OR, 1.56; 95% CI, 1.27‐1.93; P < .001), and need for mechanical ventilation (OR, 1.63; 95% CI, 1.30‐2.03; P < .001). Conclusions MetS is a better prognostic indicator for severe disease outcomes in patients with COVID‐19 than its individual components. Patients with MetS had significantly higher mortality, increased ICU admissions, and need for mechanical ventilation.