Open Access膳食胆碱摄入量与糖尿病的关系:美国国民健康与营养调查2007‐2010
Author(s) -
Zhou Long,
Li Xiang,
Li Shuhong,
Wen Xiaoxiao,
Peng Yaguang,
Zhao Liancheng
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13143
Subject(s) - medicine , national health and nutrition examination survey , choline , quartile , diabetes mellitus , odds ratio , confidence interval , confounding , logistic regression , population , receiver operating characteristic , endocrinology , environmental health
Background Little is known about the relationship between dietary intake of choline, which is a major dietary precursor for gut microbiome‐derived trimethylamine N‐oxide (TMAO), and diabetes mellitus (DM) in the general population. The present study aims to explore the relationship between dietary choline intake and DM in the US adult population. Methods Cross‐sectional data were derived from the National Health and Nutrition Examination Survey (NHANES) 2007‐2010 of 8621 individuals aged 20 years or older. Multivariable logistic regression models were used to determine odds ratios (ORs) and 95% confidence intervals (CIs) for DM of each quartile category of energy‐adjusted choline intakes. The restricted cubic spline model was used for the dose–response analysis. The receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value of choline intake for predicting DM. Results A linear dose–response relationship between dietary choline intake and the odds of DM was found after adjustment for multiple potential confounding factors. With the lowest quartile category of choline as the reference, the multivariable‐adjusted ORs and 95% CIs of the second, third, and highest quartile categories were 1.23 (0.99‐1.53), 1.27 (1.02‐1.58), and 1.49 (1.20‐1.85), respectively, P for trend =0.0004. The ROC analysis identified energy‐adjusted choline of 331.7 mg/8.37‐MJ per day as the optimal cutoff value for predicting DM, with 52.5% sensitivity and 60.7% specificity. Conclusion This study supports a positive and linear relationship between dietary choline intake and DM in the US adult population.