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open-access-imgOpen Access降糖药物对SARS‐CoV‐2的潜在影响
Author(s)
Qu Hua,
Zheng Yi,
Wang Yuren,
Li Hongwei,
Liu Xiufei,
Xiong Xin,
Zhang Linlin,
Gu Jing,
Yang Gangyi,
Zhu Zhiming,
Zheng Hongting,
Ouyang Qin
Publication year2021
Publication title
journal of diabetes
Resource typeJournals
PublisherWiley Publishing Asia Pty Ltd
Abstract Background Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), is currently posing significant threats to public health worldwide. It is notable that a substantial proportion of patients with sever COVID‐19 have coexisting diabetic conditions, indicating the progression and outcome of COVID‐19 may relate to diabetes. However, it is still unclear whether diabetic treatment principles can be used for the treatment of COVID‐19. Methods We conducted a computational approach to screen all commonly used clinical oral hypoglycemic drugs to identify the potential inhibitors for the main protease (M pro ) of SARS‐CoV‐2, which is one of the key drug targets for anti‐COVID‐19 drug discovery. Results Six antidiabetic drugs with docking scores higher than 8.0 (cutoff value), including repaglinide, canagliflozin, glipizide, gliquidone, glimepiride, and linagliptin, were predicted as the promising inhibitors of M pro . Interestingly, repaglinide, one of the six antidiabetic drugs with the highest docking score for M pro , was similar to a previously predicted active molecule nelfinavir, which is a potential anti‐HIV and anti‐COVID‐19 drug. Moreover, we found repaglinide shared similar docking pose and pharmacophores with a reported ligand (N3 inhibitor) and nelfinavir, demonstrating that repaglinide would interact with M pro in a similar way. Conclusion These results indicated that these six antidiabetic drugs may have an extra effect on the treatment of COVID‐19, although further studies are necessary to confirm these findings.
Subject(s)antiretroviral therapy , canagliflozin , covid-19 , diabetes mellitus , disease , drug , drug repositioning , endocrinology , glimepiride , glipizide , human immunodeficiency virus (hiv) , infectious disease (medical specialty) , linagliptin , medicine , nelfinavir , pharmacology , repaglinide , saquinavir , type 2 diabetes , viral load , virology
Language(s)English
SCImago Journal Rank0.949
H-Index43
eISSN1753-0407
pISSN1753-0393
DOI10.1111/1753-0407.13135

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