Open Access电生理验证针灸对2型糖尿病周围神经病变的影响:随机、部分双盲的ACUDIN对照试验
Author(s) -
MeyerHamme Gesa,
Friedemann Thomas,
Greten Johannes,
Gerloff Christian,
Schroeder Sven
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13130
Subject(s) - medicine , acupuncture , placebo , sural nerve , randomized controlled trial , diabetes mellitus , diabetic neuropathy , peripheral neuropathy , nerve conduction velocity , surgery , anesthesia , pathology , endocrinology , alternative medicine
Background Acupuncture is commonly used in Traditional Chinese Medicine for treatment of diabetic peripheral neuropathy (DPN), but data from randomized controlled trials are rare. Methods This randomized, placebo‐controlled, partially double‐blinded clinical trial randomly assigned adults with confirmed type 2 diabetes‐induced DPN to receive 10 sessions of needle acupuncture, laser acupuncture, or placebo laser acupuncture for 10 consecutive weeks. Treatment was provided at bilateral acupoints Ex‐LE‐10 (Bafeng), Ex‐LE‐12 (Qiduan), and ST‐34 (Lianqiu). Neurological assessments, including nerve conduction studies (NCS) of sural and tibial nerves, were performed at baseline and weeks 6 and 15. Primary outcome was delta of sural sensory nerve action potential (SNAP). Secondary outcomes included further NCS values, clinical scores, and patient‐reported outcome measures (PROMs). Results Of 180 participants, 172 completed the study. Sural SNAP and sural and tibial nerve conduction velocities improved significantly after 10 treatments when comparing needle acupuncture to placebo. Needle acupuncture showed earlier onset of action than laser acupuncture. PROMs showed larger improvements following needle and laser acupuncture than placebo, reaching significant differences for hyperesthesia and cramps following needle acupuncture and for heat sensation following laser acupuncture. Conclusions Classical needle acupuncture had significant effects on DPN. Improvement in NCS values presumably indicates structural neuroregeneration following acupuncture.