Open Access月经初潮年龄、理想的心血管健康指标和成年后糖尿病患病风险:来自REACTION研究的发现
Author(s) -
Hu Chunyan,
Zhang Yi,
Zhang Jie,
Huo Yanan,
Wan Qin,
Li Mian,
Qi Hongyan,
Du Rui,
Zhu Yuanyue,
Qin Yingfen,
Hu Ruying,
Shi Lixin,
Su Qing,
Yu Xuefeng,
Yan Li,
Qin Guijun,
Tang Xulei,
Chen Gang,
Xu Min,
Wang Tiange,
Zhao Zhiyun,
Chen Yuhong,
Gao Zhengnan,
Wang Guixia,
Shen Feixia,
Luo Zuojie,
Chen Li,
Li Qiang,
Ye Zhen,
Zhang Yinfei,
Liu Chao,
Wang Youmin,
Wu Shengli,
Yang Tao,
Deng Huacong,
Chen Lulu,
Zhao Jiajun,
Mu Yiming,
Wang Weiqing,
Xu Yu,
Bi Yufang,
Lu Jieli,
Ning Guang
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13128
Subject(s) - medicine , menarche , diabetes mellitus , odds ratio , confidence interval , population , logistic regression , national health and nutrition examination survey , endocrinology , demography , environmental health , sociology
Background Age at menarche was reported to be associated with the risk of diabetes. However, the impact of ideal cardiovascular health metrics (ICVHMs) on the association between age at menarche and adulthood diabetes risk was unclear. Methods We included 121 431 women from the nationwide, population‐based cohort of the REACTION study (Risk Evaluation of Cancers in Chinese Diabetic Individuals: a Longitudinal Study). The diagnosis of diabetes was based on the oral glucose tolerance test (OGTT) and glycosylated hemoglobin (HbA1c) measurement. Logistic regression and multiplicative interaction analysis were conducted to investigate the potential interaction effect between age at menarche and ICVHMs on the development of diabetes. Results The multivariable‐adjusted odds ratios of diabetes across categories of age at menarche (<14, 14‐17, and > 17 years) were 1.22 (95% confidence interval [CI]: 1.17, 1.28), 1.00 (reference), and 0.89 (95% CI: 0.85, 0.93), respectively. In subgroup analysis, significant interactions were detected between total cholesterol/blood pressure levels and age at menarche regarding the risk of diabetes ( P for interaction = .0091 and .0019, respectively). The increased risk associated with age at menarche <14 years was observed in participants with three or fewer ICVHMs, but not in women with four or more ICVHMs ( P for interaction = .0001). Conclusions Age at menarche was inversely associated with the risk of diabetes in adulthood in Chinese women, and it appeared to be modified by the presence of ICVHMs. Further studies are needed to clarify the precise interrelationship and the generalizability of our results.