Open Access1型糖尿病儿童的乳糜泻在世界各地各不相同:一项对来自SWEET注册中心的57375名患者进行的国际横断面研究
Author(s) -
Taczanowska Anna,
Schwandt Anke,
Amed Shazhan,
TóthHeyn Péter,
KanakaGantenbein Christina,
Volsky Sari Krepel,
Svensson Jannet,
Szypowska Agnieszka
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13126
Subject(s) - medicine , diabetes mellitus , body mass index , type 1 diabetes , cross sectional study , population , disease , type 2 diabetes , demography , pediatrics , obesity , endocrinology , environmental health , pathology , sociology
Background Children with type 1 diabetes (T1D) are at much higher risk of developing celiac disease (CD) than the general population. The aim of the study was to assess the prevalence and differences in clinical presentation of CD in T1D in different regions of the world. Methods This study is based on the Better control in Pediatric and Adolescent diabete S : W orking to cr E ate c E n T ers of Reference (SWEET) database. There were 57 375 patients included in the study, aged ≤18 years from 54 SWEET centers. Only centers with screening for celiac disease were included. Regression models adjusted for age, diabetes duration, and gender and a fixed effect in the models for region was used. Diabetes duration, age at diabetes onset, and sex were presented as unadjusted results. Results CD was present in 2652 subjects (4.5%), with different prevalence among regions: from 1.9% in Asia/Middle East to 6.9% in Australia/New Zealand. CD was observed more often among females. Comparing children with and without CD, characteristics for those with CD were younger age at diabetes onset (6.3 [3.3; 9.8] vs 8.1 [4.6; 11.3], P < 0.001) and had longer diabetes duration (6.4 [3.6; 9.8] vs 4.8 [2.1; 8.2], P < 0.001). Further, they had lower glycosylated hemoglobin (HbA1c) in Europe and North America/Canada; lower body mass index (BMI)‐SD score (BMI‐SDS) in southern Europe, North America, and Canada; In most regions daily insulin dose was lower, height‐SDS was lower, and the percentage of insulin pump users was higher in children with T1D and CD. Conclusions The prevalence and the anthropometric and metabolic consequences of CD in children with T1D differ around the world.