Open AccessTG/HDL‐C比值变化轨迹与2型糖尿病发病风险的关系:一项中国回顾性队列研究
Author(s) -
Zhang Yanyan,
Qin Pei,
Lou Yanmei,
Zhao Ping,
Li Xue,
Qie Ranran,
Wu Xiaoyan,
Han Minghui,
Huang Shengbing,
Zhao Yang,
Liu Dechen,
Wu Yuying,
Li Yang,
Yang Xingjin,
Zhao Yang,
Feng Yifei,
Wang Changyi,
Ma Jianping,
Peng Xiaolin,
Chen Hongen,
Zhao Dan,
Xu Shan,
Wang Li,
Luo Xinping,
Zhang Ming,
Hu Dongsheng,
Hu Fulan
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13123
Subject(s) - medicine , odds ratio , confidence interval , confounding , logistic regression , body mass index , type 2 diabetes mellitus , retrospective cohort study , cohort , type 2 diabetes , diabetes mellitus , cohort study , endocrinology
Background The association of ratio of triglycerides to high‐density lipoprotein cholesterol (TG/HDL‐C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL‐C ratio change trajectory. Methods A total of 18 444 participants aged 18‐80 years old were included in this cohort study. Linear regression and quadratic regression models were used to determine the TG/HDL‐C ratio change trajectory. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TG/HDL‐C ratio change trajectory and probability of T2DM. Results T2DM developed in 714 participants during a median follow‐up of 5.74 years (92 076.23 person‐years of follow‐up). After adjusting for baseline potential confounders, odds of T2DM were greater for participants with the increasing, U‐shape, bell‐shape, and other shape change vs decreasing change (adjusted OR [aOR] 2.01, 95% CI 1.42‐2.81; 1.56, 1.15‐2.13; 1.60, 1.17‐2.20; and 1.49, 1.13‐2.00, respectively). The results were robust in the sensitivity analyses on excluding baseline participants with T2DM. Moreover, the associations remained significant with male sex, age <60 years and body mass index <24 kg/m 2 . Conclusions This retrospective study revealed increased probability of T2DM with increasing, U‐shape, bell‐shape, and other‐shape TG/HDL‐C ratio change trajectories, especially with male sex, age <60 years and body mass index <24 kg/m 2 .