Open Access合并糖尿病的新型冠状病毒肺炎患者临床特征及预后:中国一项多中心回顾性研究
Author(s) -
Yi Huahua,
Lu Fangying,
Jin Xiaoyan,
Chen Rong,
Liu Bing,
Dong Xuan,
Xiong Weining,
Yang Dexiang,
Guo Yi,
Zhou Min
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13098
Subject(s) - medicine , interquartile range , diabetes mellitus , retrospective cohort study , ards , intensive care unit , comorbidity , lung , endocrinology
Background Coronavirus disease 2019 (COVID‐19) emerged in December 2019 and has spread globally. Diabetics are at increased risk of infections caused by a variety of pathogens including viruses. The present research aims to describe clinical characteristics and outcomes of COVID‐19 patients with diabetes. Methods A retrospective multicenter study of COVID‐19 patients with diabetes was conducted in four hospitals in Wuhan, Shanghai, and Anhui Province. Reverse transcription polymerase chain reaction or next‐generation sequencing was carried out to confirm the existence of severe acute respiratory syndrome coronavirus 2 from respiratory specimens. Results A total of 54 diabetics (10.36%) were recruited from among 521 COVID‐19 patients, with a median age of 63 (interquartile range, 52‐70) years. Among them, 51 had been previously diagnosed with diabetes and 3 had been newly diagnosed based on glycosylated hemoglobin over 6.5%. For COVID‐19, 47 of the 54 patients had an exposure history. Fever (47/54, 87.04%), dry cough (36/54, 66.67%), and expectoration (21/53, 39.62%) were among the top three symptoms. Lung infiltration was bilateral (46/52, 88.46%) and multilobe (47/52, 90.38%), and ground‐glass opacity (36/37, 97.30%) was the most common pattern in radiological images. Moreover, COVID‐19 patients with diabetes were prone to be classified as severe or critical cases (46.30%, 25/54) and had complications such as acute lung injury, acute respiratory distress syndrome, and acute kidney injury. The proportions of intensive care unit (ICU) admissions and deaths among the COVID‐19 diabetics were 14.81% (8/54) and 12.96% (7/54), respectively. Conclusions With older age, diabetics diagnosed as having COVID‐19 were prone to develop into severe cases and exhibited a high rate of ICU admission and mortality.