Open Access使用自我报告问卷和可替宁水平确认的131 724名韩国未吸烟者中二手烟暴露与糖尿病之间的关系:性别差异
Author(s) -
Kim Byung Jin,
Kim Ji Hye,
Kang Jeong Gyu,
Kim Bum Soo,
Kang Jin Ho
Publication year - 2021
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13082
Subject(s) - medicine , cotinine , diabetes mellitus , secondhand smoke , odds ratio , passive smoking , logistic regression , population , nicotine , environmental health , endocrinology
Objective The aim of this study is to compare the gender‐different associations between secondhand smoke (SHS) exposure and diabetes in self‐reported never smokers verified by cotinine. Methods Self‐reported never smokers verified by cotinine levels (<50 ng/mL) enrolled in the Kangbuk Samsung Health Study between April 2011 and December 2016 were included for this study. SHS exposure was defined as current exposure to passive smoke indoors at home or workplace. The gender‐specific association between SHS exposure and diabetes was assessed using multivariable regression analyses. Results Of the total 131 724 individuals (mean age 35 years, SD 7.1 years), 66.8% were female, and the prevalence of SHS exposure in the entire population was 22.9%. The prevalence of diabetes in the group exposed to SHS was higher than that in the group unexposed to SHS only in females (1.8% vs 1.2%, P < .001 for females; 2.2% vs 2.2%, P = .956 for males). A significant gender interaction existed for the relationships between SHS exposure and diabetes ( P for interaction <.001). The multivariate regression model showed that SHS exposure was significantly associated with diabetes only in females (odds ratio [95% CI], 1.40 [1.20, 1.65] for females; 1.00 [0.85, 1.19] for males). In particular, females with SHS exposure ≥1 hour/day, ≥3 times/week, and ≥10 years showed an increased risk of diabetes by more than 50% compared to those without SHS exposure. Conclusions SHS exposure was significantly associated with diabetes in female never smokers with dose‐dependent relationship. However, further longitudinal studies are needed to elucidate the gender difference in the incidence of diabetes associated with SHS exposure.