Open Access50 g葡萄糖负荷试验在预测小于胎龄儿中的应用
Author(s) -
Tanacan Atakan,
Eyupoglu Mert,
Fadiloglu Erdem,
Zengin Hatice Yagmur,
Karaagaoglu Ergun,
Beksac Mehmet Sinan
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13068
Subject(s) - medicine , percentile , small for gestational age , cutoff , logistic regression , odds ratio , retrospective cohort study , receiver operating characteristic , gestational age , obstetrics , pregnancy , statistics , mathematics , physics , quantum mechanics , biology , genetics
Background To determine a cutoff value for the 50‐g glucose challenge test (50‐g GCT) for the prediction of small‐for‐gestational‐age (SGA) neonates. Methods This retrospective cohort study was conducted among pregnant women who were screened with the 50‐g GCT at Hacettepe University Hospital between 1 January 2016 and 31 March 2019. Patients with 50‐g GCT values <74 mg/dL (<10th percentile) served as the study group (n = 244), while patients with 50‐g GCT values between 74 to 139 mg/dL served as the control group (n = 3104). Groups were compared in terms of demographic features, clinical characteristics, and obstetric outcomes. Logistic regression analysis was used to determine independent predictors of SGA. Receiver operating characteristic curves were used to assess the performance of 50‐g GCT values in predicting SGA. Results Lower birthweight, birthweight percentile, and 5th‐minute Apgar values, together with higher rates of SGA, were observed in the study group ( P < .001 for all). A 50‐g GCT value below the 10th percentile (odds ratio: 3.29, 95% CI: 2.31‐4.69, P < .001) was a significant independent factor for SGA. A cutoff value of 89.5 mg/dL (84.9% sensitivity, 85.6% specificity) was determined for SGA. Conclusions Low 50‐g GCT values (<89.5 mg/dL) may be an early indicator for SGA.