Open Access肌肉量和腰围对日本中年人2型糖尿病的联合影响:循环系统风险的社区研究(CIRCS)
Author(s) -
Yasuoka Mikako,
Muraki Isao,
Imano Hironori,
Jinnouchi Hiroshige,
Kubota Yasuhiko,
HayamaTerada Mina,
Umesawa Mitsumasa,
Yamagishi Kazumasa,
Ohira Tetsuya,
Kitamura Akihiko,
Okada Takeo,
Kiyama Masahiko,
Iso Hiroyasu
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13049
Subject(s) - medicine , type 2 diabetes , skeletal muscle , diabetes mellitus , endocrinology , abdominal obesity , waist , odds ratio , sarcopenia , body mass index
Background Although evidence about skeletal muscle mass loss and type 2 diabetes risk has accumulated, little information is available on the combined effect of skeletal muscle mass and abdominal obesity on type 2 diabetes. We examined whether skeletal muscle mass and abdominal obesity were synergistically associated with the prevalence of type 2 diabetes. Methods Skeletal muscle mass and waist circumference (WC) were measured in 1515 Japanese aged 40 to 69 years. Relative muscle mass was calculated as percentage of total skeletal muscle mass in body weight (SMM%). Type 2 diabetes was identified as fasting serum glucose ≥7.0 mmol/L (126 mg/dL), nonfasting serum glucose ≥11.1 mmol/L (200 mg/dL), glycosylated hemoglobin ≥ 6.5%, and/or diabetes medication use. Results The multivariable‐adjusted odds ratio (OR) of prevalent diabetes from the lowest to the third quartile of SMM% compared to the highest quartile gradually increased in both sexes. The association between a high WC and prevalent diabetes was similar. The multivariable‐adjusted OR (95% confidence intervals) for the prevalence of type 2 diabetes in the low skeletal muscle mass/high WC group was 3.19 (1.78‐5.71) for men and 4.46 (2.09‐9.51) for women compared with the high skeletal muscle mass/low WC group. The relative excess risk due to interaction was 2.2 (0.5‐3.9) in men and 2.8 (0.2‐5.3) in women for an excess burden of type 2 diabetes for low skeletal muscle mass and high WC. Conclusions Low skeletal muscle mass and abdominal obesity were synergistically associated with presence of type 2 diabetes.