Open Access阻塞性睡眠呼吸暂停综合征和2型糖尿病发病风险:队列研究的系统评价和剂量‐反应meta分析
Author(s) -
Qie Ranran,
Zhang Dongdong,
Liu Leilei,
Ren Yongcheng,
Zhao Yang,
Liu Dechen,
Liu Feiyan,
Chen Xu,
Cheng Cheng,
Guo Chunmei,
Li Quanman,
Zhou Qionggui,
Tian Gang,
Han Minghui,
Huang Shengbing,
Wu Xiaoyan,
Qin Pei,
Li Jianxin,
Cao Jie,
Zhang Ming,
Huang Jianfeng,
Lu Jie,
Li Honghui,
Wang Jian,
Cheng Ruirong,
Hu Dongsheng
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13017
Subject(s) - medicine , obstructive sleep apnea , meta analysis , type 2 diabetes mellitus , relative risk , cohort study , apnea–hypopnea index , sleep apnea , cohort , diabetes mellitus , apnea , confidence interval , polysomnography , endocrinology
Background This meta‐analysis was performed to quantitatively evaluate the dose‐response association between obstructive sleep apnea (OSA) and risk of type 2 diabetes mellitus (T2DM). Methods PubMed, Embase, and Web of Science were searched up to 12 December 2018 for articles that assessed the OSA‐T2DM association. Random effects models were used to analyze the quantitative association between OSA and risk of T2DM. Restricted cubic splines were used to model the dose‐response association between apnea‐hypopnea index (AHI), used to assess the severity of OSA according to events/h, and risk of T2DM. Results We included 16 cohort studies in our meta‐analysis. During a median follow‐up of 10.5 years (range: 3.0‐22.0), 19 355 T2DM cases were reported among 338 912 study participants. The pooled relative risk of T2DM was 1.40 (95% CI, 1.32‐1.48) for OSA in the binary meta‐analysis and 1.08 (1.01‐1.14) for each 5‐event/h increase in AHI value. We found a positive linear association between OSA and T2DM risk. Conclusions Our dose‐response meta‐analysis revealed a linear association between OSA and T2DM.