Open Access妊娠期糖尿病胰岛素抵抗增高提示不良妊娠结局
Author(s) -
Sun YiYing,
Juan Juan,
Xu QianQian,
Su RiNa,
Hirst Jane E.,
Yang HuiXia
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13013
Subject(s) - medicine , gestational diabetes , insulin resistance , pregnancy , obstetrics , body mass index , confounding , diabetes mellitus , gestation , endocrinology , genetics , biology
Background This study aimed to investigate the association between maternal insulin resistance (IR) in the late second trimester and pregnancy outcomes, as well as to identify risk factors of IR among women with gestational diabetes mellitus (GDM). Methods A retrospective study was conducted among 2647 women diagnosed with GDM. IR was evaluated using the homeostasis model assessment method for IR (HOMA‐IR) in the late second trimester (between 24 and 28 weeks), and the lipid profiles were measured at the same time. Patients were divided into groups based on quartiles of HOMA‐IR. The information on pregnancy outcomes and risk factors was extracted from the medical records of all participants and entered electronically. Logistic regression models were used to analyze the associations between HOMA‐IR and pregnancy outcomes, as well as the associations between risk factors and HOMA‐IR. Results Greater IR was associated with cesarean delivery, preterm delivery, macrosomia, and large for gestational age newborns, but only significantly associated with preterm delivery after adjustment for potential confounders ( P < .001). Prepregnancy body mass index (BMI), weight gain before diagnosis of GDM, and triglycerides were significantly related with IR in the late second trimester ( P < .001). Besides, the total area under the curve of the diagnostic 75‐g oral glucose tolerance test and glycosylated hemoglobin A1c increased from the lowest to the highest HOMA‐IR groups. Conclusions Increasing IR in the late second trimester predicts adverse pregnancy outcomes especially for preterm delivery in women with GDM. Additionally, prepregnancy BMI and weight gain before diagnosis of GDM are independent risk factors for the development of IR.