Open Access中国从未吸烟女性环境烟雾暴露与2型糖尿病的风险关联:一项基于人群的队列研究
Author(s) -
Huang Chunyan,
Chen Gang,
Zhang Mingzhi,
Lu Yan,
Hua Yujie,
Hu Yihe,
Jin Jianrong,
Zhou Jinyi,
Bian Zheng,
Guo Yu,
Li Liming,
Chen Zhengming,
Zhang Jun
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.13001
Subject(s) - medicine , diabetes mellitus , cohort , tobacco smoke , smoke , type 2 diabetes mellitus , cohort study , environmental health , endocrinology , physics , meteorology
Background Evidence for the association between environmental tobacco smoke (ETS) exposure and the risk of type 2 diabetes mellitus (T2DM) is limited. The aim of this study was to investigate this association in female never smokers. Methods We analyzed 28 177 female participants of the China Kadoorie Biobank (CKB) in the Suzhou area, who were never smokers and had no diabetes. ETS exposure was defined as being exposed to other people's tobacco smoke either at home, workplace, or in public places at least 1 d/wk. Cox proportional hazard regression models were used to assess the association between ETS exposure and incident T2DM according to the frequency and duration of ETS exposure. Results A total of 774 incident cases of T2DM were identified during a median 7.3‐year follow‐up. Compared with no ETS exposure, hazard ratios (95% CIs) for all ETS exposure, daily, and ≥ 14 h/wk ETS exposure were 1.17 (1.00‐1.37), 1.23 (1.04‐1.46), and 1.25 (1.03‐1.53), respectively. Moreover, a positive dose‐response relationship was observed between ETS exposure level and T2DM (all P <.05 for trend). Conclusions This prospective study suggests that ETS exposure increases the risk of T2DM incidence with dose‐response relationship in female never smokers. Thus, reducing ETS exposure may help decrease the burden of T2DM in Chinese females.