Open Access中国成人抑郁和肥胖交互作用对2型糖尿病的影响
Author(s) -
Ning Feng,
Zhang Dong,
Xue Bai,
Zhang Lei,
Zhang Jintai,
Zhu Zhigang,
Zhang Dongfeng,
Gao Ruqin,
Pang Zengchang,
Qiao Qing
Publication year - 2020
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12968
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , depression (economics) , incidence (geometry) , body mass index , obesity , confounding , confidence interval , logistic regression , endocrinology , physics , optics , economics , macroeconomics
Background Cross‐sectional studies have supported the association among depression, obesity, and type 2 diabetes, but the causality remains controversial in Chinese adults. In this longitudinal study, we evaluated the synergistic effect of depression and obesity on the risk of type 2 diabetes. Methods This study included 2809 participants randomly selected from the Qingdao Diabetes Prevention Program, and their type 2 diabetes incidence was determined over a follow‐up period of 3 years. The WHO 2006 criteria and the Zung Self‐Rating Depression Scale score were employed to identify type 2 diabetes and depression at baseline, respectively. Multivariable‐adjusted logistic regression was used to evaluate the synergistic effects of depression and obesity indicators on type 2 diabetes, with adjustment for age, sex, family history of diabetes, and other potential risk factors. Results During 3‐year follow‐up, 316 new incident cases were identified. The relative risk and 95% confidence interval of depression for diabetes incidence was 1.52 (1.05‐2.21), after controlling for potential confounders. Sensitivity analysis showed that depression was significantly associated with diabetes incidence in women, younger people, and obese people (1.82 [1.14‐2.92], 1.94 [1.25‐3.02], and 4.29 [1.44‐12.78], respectively]. The synergistic effects of positive depression and body mass index ≥30 kg/m 2 on type 2 diabetes incidence were observed, with a synergy index of 5.49 (1.75‐17.19). Conclusions Depression was associated with a 52% increased risk of type 2 diabetes incidence and exerts synergistic effects with obesity on diabetes incidence in Chinese adults. Early identification and intervention for depression and obesity can reduce the risk of diabetes.