Open Access糖尿病表型:在IDDM与NIDDM以外
Author(s) -
Bloomgarden Zachary,
Drexler Andrew
Publication year - 2019
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12954
Subject(s) - medicine , insulin resistance , diabetes mellitus , insulin , autoimmunity , type 2 diabetes , disease , endocrinology
An older nosology of diabetes distinguished two major groups, the “insulin-dependent” and “noninsulin-dependent.” Some argued that this was no more a definition of real subgroups than would be characterization of cases of pneumonia as those responding or not responding to a given antibiotic. A myriad of factors leading to hyperglycemia have been delineated, including islet autoimmunity, insulin secretory defects, resistance to insulin action, and obesity, but efforts to better characterize diabetes phenotypes have not been widely accepted. We currently term diabetes as type 1 and type 2, with recognition of the former as an autoimmune disease directed at the β-cell. Type 2 diabetes is, however, a complex disease in which both insulin resistance and insulin deficiency play roles. To be worthwhile,novel approaches to phenotyping type 2 diabetes would provide improvement both in therapeutic decision making and in assessing risk of diabetes-related complications.