Open Access中国人群奶制品摄入与慢性代谢性疾病之间的剂量‐反应关系
Author(s) -
Guo Panpan,
Zhu Henan,
Pan Hongzhi,
Feng Rennan,
Chen Yichi,
Wang Yan,
Wang Xuemei,
Li Yong,
Yang Lei,
Zhou Beijia,
Wang Xin,
Zhao Yan
Publication year - 2019
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/1753-0407.12921
Subject(s) - medicine , diabetes mellitus , population , chinese population , environmental health , endocrinology , biochemistry , chemistry , genotype , gene
Background This study investigated associations between dairy intake and chronic metabolic diseases (CMDs), and evaluated possible dose‐response relationships in Chinese. Methods This cross‐sectional study included 6073 adults aged ≥18 years from China. General characteristics were gathered using a validated dietary questionnaire. Multivariable logistic regression analyses investigated associations between dairy intake and chronic metabolic diseases (CMDs) (overweight/obesity, obesity, central obesity, and hyperlipidemia). Restricted cubic spline models explored dose‐response relationships between dairy intake and CMDs, and possible dairy intake in the prevention of CMDs. Structural equation modeling explored the potential mechanisms of the effects of dairy intake on CMDs. Results Significant inverse associations were found between dairy intake and overweight/obesity, obesity, central obesity, and hyperlipidemia, with odds ratios (ORs) of 0.66 (95% confidence interval [CI] 0.56‐0.79), 0.63 (95% CI 0.47‐0.85), 0.71 (95% CI 0.60‐0.85), and 0.81 (95% CI 0.56‐1.17), respectively ( P < 0.05 for all). The intake of yogurt, milk, and total dairy to prevent CMDs differed according to age group (16‐74, 29‐187, and 159‐269 mL/d, respectively, in the entire group; 69‐110, 59‐152, and 138‐167 mL/d, respectively, in the young group, ≤ 44 years; 9‐58, 57‐149, and 117‐145 mL/d, respectively, in the middle‐aged group, 45‐59 years; and 23‐59 mL/d yogurt only in the old group, ≥ 60 years). Structural equation modeling showed that dairy intake could reduce body mass index and waist circumference by regulating carbohydrate, fat, protein, and total energy. Conclusions Dairy intake was inversely associated with the prevalence of overweight, obesity, central obesity, and hyperlipidemia, and the optimal range of dairy intake differed with age. The beneficial effects of dairy intake in preventing CMDs could involve regulation of carbohydrate, fat, protein, and total energy.